As soon as antibiotics were discovered and
developed for medical use, bacteria began the Darwinian "arms race"
that has been fought ever since, with pathogens developing resistance to
antibiotics, necessitating continual development of new types of medications
and increasingly difficult infect agents arising with increasing regularity.
Some of the most informed experts have been warning that humans are now
starting to lose more of these battles every year. The specter of untreatable
and virulent outbreaks, local or pandemic, increases with each decade; as a
review put it a decade ago, "Antimicrobial resistance has reached
crisis stage in human medicine."